ABSTRACT
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1-9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC
Subject(s)
Antineoplastic Agents/pharmacology , Cell Line, Tumor , Crystallography, X-Ray , Fungi , Molecular Structure , PhomopsisABSTRACT
The chemical composition of Mangifera indica L. cv. "Kent" leaves was determined by HPLC-ESI-QTOF-MS/MS. Polyphenolic compounds characterized as benzophenone derivatives were the main components found in extracts (1, maclurin 3-C-(2-O-galloyl)-D- glucoside isomer; 2, maclurin 3-C-ï¢--D-glucoside; 3, iriflophenone 3-C-ï¢--D-glucoside; 5, maclurin 3-C-(2,3-di-O-galloyl)-ï¢--D-glucoside; 6, iriflophenone 3-C-(2-O-galloyl)-ï¢--D-glucoside; 7, methyl-iriflophenone 3-C-(2,6-di-O-galloyl)-ï¢--D-glucoside) and xanthones (4, mangiferin and 8, 6-O-galloyl-mangiferin). The estrogenic and antioxidant effects of aqueous extracts from Mangifera indica L. cv. "Kent" leaves on ovariectomized rats were determined by uterotrophic assay and malondialdehyde (MDA) levels in erythrocytes, bone, liver, and stomach. We conclude that the polyphenolic compounds from extracts act as exogenous antioxidant agents against oxidative damage in ovariectomized rats.
La composicioÌn quiÌmica de las hojas de Mangifera indica L. cv. "Kent" se determinoÌ por HPLC-ESI-QTOF-MS/MS. Compuestos polifenoÌlicos caracterizados como derivados de benzofenona fueron los componentes principales encontrados en los extractos (1, isoÌmero de la maclurina 3-C-(2-O-galoyil)-D-glucoÌsido; 2, maclurina 3-C-ß-D-glucoÌsido; 3, iriflofenona 3-C-ß-D-glucoÌsido; 5, maclurina 3-C-(2,3-di-O-galloiÌl)-ß-D-glucoÌsido; 6, iriflofenona 3-C-(2-O-galloil)-ß-D-glucoÌsido; 7, metil-iriflofenona 3-C-(2,6-di-O- galloyl)-ß-D-glucoÌsido) y xantonas (4, mangiferina y 8, 6-O-galoyil-mangiferina). Los efectos estrogeÌnicos y antioxidantes de los extractos acuosos de hojas de Mangifera indica L. cv. "Kent" en ratas ovariectomizadas se determinaron mediante ensayo uterotroÌfico y la medicioÌn de los niveles de malondialdehiÌdo (MDA) en eritrocitos, huesos, hiÌgado y estoÌmago. Concluimos que los compuestos polifenoÌlicos de los extractos actuÌan como agentes antioxidantes exoÌgenos contra el danÌo oxidativo en ratas ovariectomizadas.